Dr. P. Ravi Selvaganapathy

Dr. Ravi Selvaganapathy

Associate Professor
Canada Research Chair in Biomicrofluidics

McMaster University
Department of Mechanical Engineering
Hamilton, Ontario, Canada L8S 4L7

Office: JHE 212B (Mail to JHE-316)
Email:
Voice: (905) 525-9140 x27435
Fax: (905) 572-7944
Website: CAMEF

 

  • B.S (Chemical and Electrochemical Engineering), Central Electrochemical Research Institute, 1998
    M.S, University of Michigan, 2001
    Ph.D (Electrical Engineering) University of Michigan, 2002

Research Interests

  • Microelectromechanical (MEMS) devices
  • Fluid mechanics
  • Micro-fluidics & micro-fabrication
  • Renewal & sustainable energy systems
  • Biomechanics

Specific Research Activities

 

My research interests, broadly, are in the design, fabrication and development of microdevices for application in biology, medicine. In addition, I have an interest in application of microfluidics to thermal management. Specifically, I am interested in use of microfabrication techniques - conventionally used in microelectronic industry – in parallel fabrication of precise and low cost microfluidic devices that could perform chemical and biological unit operations. At a more fundamental level, I am interested in the understanding and the use of electrically driven flows for transport and control in these devices as these are the dominant effects in the microscale.

Currently, my research focuses on developing microfluidic devices for application in drug discovery, medical/environmental diagnosis and drug delivery. In addition, we are active in developing solutions for thermal management of electronics using microfluidics. Our group has developed microfabrication procedures and process flows for incorporating novel materials such as paraffin, porous polymer monoliths, thermal sensitive phase change polymers, and biocompatible polyurethane in microfluidic devices.

We have then used the unique properties of these materials in design and development of microfluidic components such as micropumps, microvalves, detectors and light sources. For example, we have developed the smallest electrokinetic micropumps using porous polymer monolith, thermopneumatic microvalves using paraffin and pNIPPAM (poly N-isopropyl acrylamide), first microfluidic light source and detectors using microplasmas and the highest pressure generating electrohydrodynamic pumps for electronic cooling application.

Combining some of these components, we have also developed integrated microsystems that use these functional components with applications in medical diagnostics, drug discovery, drug delivery and electronic cooling. Some of our key accomplishments using these devices include development of the first microfluidic high throughput microinjection system for embryos, discovery of highly repeatable electrotaxis of C.elegans in microfluidic channels and demonstration of control, transport and sorting of C.elegans.

Selected Publications

  • P. Selvaganapathy, E.T. Carlen, C.H. Mastrangelo, Integrated microfabricated systems for genetic and protein analysis, in Encyclopedia of Sensors, C.A. Grimes, E.C. Dickey, M.V. Pishko (eds.), American Scientific Publishers, vol. X, 1-26, (2006).
  • N Rochow, A. Manan, W.-I Wu, G. Fusch, S. Monkman, J.Leung, E. Chan, D. Nagpal, D. Predescu, J. Brash, P. Ravi Selvaganpathy,C. Fusch, An integrated array of microfluidic oxygenators as a neonatal lung assist device: invitro characterization and invivo demonstration, Artificial Organs, 2013 (accepted)
  • S. Safari, P.R. Selvaganapathy, M.J. Deen, Microfluidic Reference Electrode with Free-Diffusion Liquid Junction, J. of Electrochemical Society, 160, B177-B183, 2013.
  • S. Salam, A. Ansari, S. Amon, P. Rezai, P.R. Selvaganapathy, R.K. Mishra, B.P. Gupta, A microfluidic phenotype analysis system reveals function of sensory and dopaminergic neuron signaling in C. elegans electrotactic swimming behavior, Worm, 2, e24558, 2013.
  • J. Tong, P. Rezai, S. Salam, P.R. Selvaganapathy, B.P. Gupta, Microfluidic-based Electrotaxis for On-demand Quantitative Analysis of Caenorhabditis elegans' Locomotion, J. Vis. Exp., 75, e50226, (2013)
  • W-I. Wu, N. Rochow, E. Chan , G. Fusch, A. Manan, D. Nagpal, P. Ravi. Selvaganapathy, C. Fusch, Lung Assist Device: Development of Microfluidic Oxygenators for Preterm Infants with Respiratory Failure, Lab on Chip, 13, 2641-2650, (2013)
  • W-I. Wu, Daniel Ewing, Chan Y. Ching, and P. Ravi Selvaganapathy, Measurement of Periodic Micro Flow Using Micro Particle Image Velocimetry with Phase Sampling, Microfluidics and Nanofluidics, 15, 127-135, (2013)
  • N. Rochow, E.C. Chan, W.-I Wu, P.R. Selvaganapathy, G. Fusch, L. Berry, J. Brash, A.K. Chan, C. Fusch, Artificial placenta - Lung assist devices for term and preterm newborns with respiratory failure, Int. J. of Artificial Organs, (2013) (DOI:10.5301/ijao.5000195)
  • D. Maznichenko, P. R. Selvaganapathy, K. Venkatakrishnan, B. Tan, TiO2 nanofibrous interface development for Raman detection of environmental pollutants, Appl. Phys. Lett., 101, 231602 (2012)
  • Z.Y. Li, M.J. Deen, Q.Y. Fang, P.R. Selvaganapathy, Design of a flat field concave-grating-based micro-Raman spectrometer for environmental applications, Applied Optics, 51, 6855-6863, 2012.
  • P. Rezai, S. Salam, P.R. Selvaganapathy, B. Gupta, Electrical sorting of Caenorhabditis elegans, Lab on Chip, 12, 1831-1840, (2012), (Impact Factor: 6.5)
  • L. Kesselmann, S. Shinwary, P.R. Selvaganapathy, T. Hoare, Synthesis of Monodisperse, Covalently-Crosslinked, Degradable “Smart” Microgels Using Microfluidics, Small, 8, 1092–1098, (2012) (Impact factor: 7.3)
  • G. Mahadevan, H. Sheardown, P. Selvaganapathy, PDMS embedded microneedles as a controlled release system for the eye, Journal of Biomaterials Applications, (2012), (Impact Factor: 2.2) (Online - DOI: 10.1177/0885328211433778)
  • W. Wu, K. Sask , J. Brash, P.R, Selvaganapathy, Polyurethane-Based Microfluidic Devices for Blood Contacting Applications, Lab on Chip, 12, 960-970, (2012), (Impact Factor: 6.5) ( in top 10 downloaded papers in Lab on Chip journal in Jan 2012)
  • P. Rezai, S. Salam, P.R. Selvaganapathy, B. Gupta, Pulse DC Electrotaxis of Nematodes Caenorhabditis elegans and Caenorhabditis briggsae, Biomicrofluidics,5, 044116(2011), (Impact Factor: 3.9) (Citations: 2)
  • M.W Shinwari, M.J Deen, P.R Selvaganapathy, The effect of DNA probe distribution on the reliability of label-free biosensors, Sens. & Act.: B. Chem., 160, 441-447,(2011) (Impact Factor: 3.3) (Citations: 3)
  • P. Rezai, P.R. Selvaganapathy, G.R. Wohl, Plasma enhanced bonding of polydimethylsiloxane (PDMS) with parylene and its optimization, Journal of Micromechanics and Microengineering, 21, 065024, (2011) (Impact Factor: 2.3) (Citations: 4)
  • S. Safari, P.Selvaganapathy, A.Deredja, J. Deen, Electrochemical growth of high-aspect ratio nanostructured silver chloride on silver and its application to miniaturized reference electrodes, Nanotechnology, 22, 315601 (2011) (Impact Factor:3.6) (featured on the cover)
  • M. Hasnain, P. Selvaganapathy, C.Y. Ching, On the Modeling and Simulation of Ion Drag Electrohydrodynamic Micropumps, Journal of Fluids Engineering, 133, 051102, (2011). (top 10 most downloaded article in June 2011)
  • W. Wu, P. Selvaganapathy, C.Y. Ching, Transport of Particles and Micro-organisms in Microfluidic Channels Using Rectified AC Electroosmotic Flow, Biomicrofluidics, 5, 013407 (2011) (Impact Factor:3.9) (selected for April 1, 2011 issue of Virtual Journal of Biological Physics Research) (Citations: 2)
  • M. Howlader, P. Selvaganapathy, M. Jamal Deen, T. Suga, Nanobonding Technology Toward Electronic, Fluidic, and Photonic Systems Integration, Journal of Selected Topics in Quantum Electronics, 17, 689-702, (2011) (Impact Factor:3.0) (Citations: 2)
  • P. Rezai, A. Siddiqui, P. Selvaganapathy, B. Gupta, Behavior of Caenorhabditis elegans in Alternating Electric Field and its Application to their Localization and Control, Applied Physics Letters, 96, 153702 (2010) (Impact Factor: 3.7) (Citations: 9)
  • K. Ou, W.I Wu, P.R. Selvaganapathy, Process Design for Reactive Ion Etching of Silicones, International Journal of Abrasive Technology, 3, 105-121, (2010) (Invited)
  • M.W Shinwari, M.J Deen, P.R Selvaganapathy, Finite-element modelling of biotransistors, Nanoscale Research Letters, 5 (3), 494-500, (2010) (Citations: 4)
  • M.W Shinwari, D. Zhitomirsky I.A. Deen, P.R. Selvaganapathy, M.J. Deen, D. Landheer,  Microfabricated reference electrodes and their biosensing applications, Sensors, 10, 1679-1715, 2010. (Citations: 18)
  • P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Influence of  3D geometry and spacing on the performance of ion drag electrohydrodynamic micropump, Journal of Electrostatics, 68, 376-383, 2010
  • S. Upadhyaya, P. Selvaganapathy, Microfluidic drug discovery platform for cell based assays, Lab on a Chip, 10, 341 – 348, (2010) (Impact Factor: 6.5) (Citations: 11)
  • P. Rezai, A. Siddiqui, P. Selvaganapathy, B. Gupta, Electrotaxis of C.elegans in a microfluidic environment, Lab on a Chip, 10, 220 – 226, (2010) (Impact Factor: 6.5)  (Citations: 22)
  • A.J. Robinson, G. O’Donnell, J. Verheggen, P. Selvaganapathy, C.Y. Ching, Development of a novel electrohydrodynamic micropump with 3D electrode geometry, International Journal of Heat and Technology, 28, 89-94 (2010)
  • S. Upadhyaya, P. Selvaganapathy, Miniaturized microfluidic formats for cell based high throughput screening, Critical Reviews in Biomedical Engineering, 37, 1-193, (2009)
  • A. Noori, P. Selvaganapathy, J. Wilson, Single cell microinjection using compliant fluidic channels with electroosmotic dosing, Lab on a Chip, 9, 3202 – 3211, (2009) (Impact Factor: 6.5) (top 10% - inside cover article) (Citations: 5)
  • P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Effect of electrode asymmetry on performance of electrohydrodynamic micropumps, Journal of Microelectromechanical Systems, 18, 547-554, (2009) (Impact Factor: 3) (Citations: 4)
  • P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Electrohydrodynamic micropumps with asymmetric electrode geometries for microscale electronics cooling, IEEE Transactions on Dielectrics and Electrical Insulation, 16, 483-488, (2009) (Citations: 5)
  • B.G. Subramani, P. Selvaganapathy, Surface Micromachining of PDMS using sacrificial photoresist, Journal of Micromechanics and Microengineering, 19,  015013 (10pp), (2009) (Impact Factor: 2.3) ( in top 3% of downloaded papers among all IOP journals in 2009) (Citations: 4)
  • M.W. Shinwari, M.J. Deen, P. Selvaganapathy, Analytic Modeling of Biotransistors, IET Circuits, Devices & Systems 2, 158-165, 2008. (Citations: 6)
  • B. Mitra, C.G. Wilson, L. Que, P. Selvaganapathy, Y.G. Gianchandani, Microfluidic discharge-based optical sources for detection of biochemicals, Lab on a Chip, 6, 60–65, (2006). (Impact Factor: 6.5) (Citations: 9)
  • L.L. Chu, K. Takahata, P. Selvaganapathy, Y.B. Gianchandani, J.L. Shohet, A micromachined kelvin probe with integrated actuator for microfluidic and solid-state applications, Journal of Microelectromechanical Systems, 14, 691-698, (2005). (Impact Factor: 3) (Citations: 10)
  • P. Selvaganapathy, E.T. Carlen, C.H. Mastrangelo, Recent progress in microfluidic devices for nucleic acid and antibody assays, Proceedings of the IEEE, 91, 954 -975, 2003. (Impact Factor: 3.4) (Citations: 27) (invited) (one of the top 20 cited papers in MEMS 2003-04)
  • C. Yu, S. Mutlu, P. Selvaganapathy, C.H. Mastrangelo, F. Svec, J.M.J. Frechet, Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers, Analytical Chemistry, 75, 1958-1961, (2003). (Impact Factor: 5.6) (Citations: 110)
  • P. Selvaganapathy, E.T. Carlen, C.H. Mastrangelo, Electrothermally actuated inline microfluidic valve Sensors and Actuators, A: Physical, 104 (3), 275-282, (2003).
  • S. Mutlu, C. Yu, P. Selvaganapathy, F. Svec, C.H. Mastrangelo, J.M.J. Frechet, Micromachined porous polymer for bubble free electro-osmotic pump, Proc. of the 15th IEEE International Conference on MicroElectroMechanical Systems (MEMS), 19 -23, (2002). 
  • C. Yu, S. Mutlu, P. Selvaganapathy, C.H. Mastrangelo, F. Svec, J.M.J. Frechet, Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers, Analytical Chemistry, 75 (8), 1958-1961, (2003).
  • W. Wu, K. Sask , J. Brash, P.R, Selvaganapathy, Polyurethane-Based Microfluidic Devices for Blood Contacting Applications, Lab on Chip, 12, 960-970, (2012)
  • P. Selvaganapathy, Y.S. Leung Ki, P. Renaud, C.H. Mastrangelo, Bubble-free electrokinetic pumping, Journal of Microelectromechanical Systems, 11 (5), 448 -453, (2002).
  • B. Mitra, C.G. Wilson, L. Que, P. Selvaganapathy, Y.G. Gianchandani, Microfluidic discharge-based optical sources for detection of biochemicals, Lab on a Chip, 6 (1), 60–65, (2006).
  • P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Effect of electrode asymmetry on performance of electrohydrodynamic micropumps, Journal of Microelectromechanical Systems, 18 (3), 547-554, (2009)
  • P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Electrohydrodynamic micropumps with asymmetric electrode geometries for microscale electronics cooling, IEEE Transactions on Dielectrics and Electrical Insulation, 16 (2), 483-488, (2009) 
  • P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Influence of  3D geometry and spacing on the performance of ion drag electrohydrodynamic micropump, Journal of Electrostatics, (2010) (accepted)
  • M.W. Shinwari, M.J. Deen, P. Selvaganapathy, Analytic Modeling of Biotransistors, IET Circuits, Devices & Systems 2(1), 158-165, 2008.
  • S. Upadhyaya, P. Selvaganapathy, Nanoporous device for accurate dose control in high throughput screening, in Proc. of ASME/IEEE MEMS 2008 Conference, Tucson, Arizona, 583-586, (2008)
  • A. Noori, P. Selvaganapathy, Single cell microinjection using compliant fluidic channels, in The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2008), San Diego, California, 1971-1973, 2008. (Top 6% of papers submitted)
  • A. Noori, P. Selvaganapathy, J. Wilson, Single cell microinjection using compliant fluidic channels with electroosmotic dosing, Lab on a Chip, 9, 3202 – 3211, (2009) (Inside cover article)
  • P. Rezai, A. Siddiqui, P. Selvaganapathy, B. Gupta, Electrotaxis of C.elegans in a microfluidic environment, Lab on a Chip, 10, 220 – 226, (2010)
  • P. Rezai, A. Siddiqui, P. Selvaganapathy, B. Gupta, Behavior of Caenorhabditis elegans in Alternating Electric Field and its Application to their Localization and Control, Applied Physics Letters, 96, 153702 (2010)
  • P. Rezai, S. Salam, P.R. Selvaganapathy, B. Gupta, Electrical sorting of Caenorhabditis elegans, Lab on Chip, 12, 1831-1840, (2012)
  • G. Mahadevan, P. Selvaganapathy, H. Sheardown, Integrated microneedle arrays and assembly techniques for drug delivery applications, in Proc. of Smart Systems Integration Conference, Barcelona, Spain, 483-486, (2008)