Dr. P. Ravi Selvaganapathy

Dr. Ravi Selvaganapathy

Associate Professor
Canada Research Chair in Biomicrofluidics

McMaster University
Department of Mechanical Engineering
Hamilton, Ontario, Canada L8S 4L7

Office: JHE 212B (Mail to JHE-316)
Email:
Voice: (905) 525-9140 x27435
Fax: (905) 572-7944
Website: CAMEF

 

  • B.S (Chemical and Electrochemical Engineering), Central Electrochemical Research Institute, 1998
    M.S, University of Michigan, 2001
    Ph.D (Electrical Engineering) University of Michigan, 2002

Research Interests

  • Microelectromechanical (MEMS) devices
  • Fluid mechanics
  • Micro-fluidics & micro-fabrication
  • Renewal & sustainable energy systems
  • Biomechanics

Specific Research Activities

My research interests, broadly, are in the design, fabrication and development of microdevices for application in biology, medicine. In addition, I have an interest in application of microfluidics to thermal management. Specifically, I am interested in use of microfabrication techniques - conventionally used in microelectronic industry – in parallel fabrication of precise and low cost microfluidic devices that could perform chemical and biological unit operations. At a more fundamental level, I am interested in the understanding and the use of electrically driven flows for transport and control in these devices as these are the dominant effects in the microscale.

Currently, my research focuses on developing microfluidic devices for application in drug discovery, medical/environmental diagnosis and drug delivery. In addition, we are active in developing solutions for thermal management of electronics using microfluidics. Our group has developed microfabrication procedures and process flows for incorporating novel materials such as paraffin [1], porous polymer monoliths [2], thermal sensitive phase change polymers [3], and biocompatible polyurethane [4] in microfluidic devices.

We have then used the unique properties of these materials in design and development of microfluidic components such as micropumps, microvalves, detectors and light sources. For example, we have developed the smallest electrokinetic micropumps using porous polymer monolith [2, 5], thermopneumatic microvalves using paraffin [1] and pNIPPAM (poly N-isopropyl acrylamide) [3], first microfluidic light source and detectors using microplasmas [6] and the highest pressure generating electrohydrodynamic pumps [7, 8, 9] for electronic cooling application.

Combining some of these components, we have also developed integrated microsystems that use these functional components with applications in medical diagnostics [10], drug discovery [11, 12, 13, 14, 15, 16], drug delivery [17] and electronic cooling [7, 8, 9]. Some of our key accomplishments using these devices include development of the first microfluidic high throughput microinjection system for embryos, discovery of highly repeatable electrotaxis of C.elegans in microfluidic channels and demonstration of control, transport and sorting of C.elegans.

Selected Publications

  1. P. Selvaganapathy, E.T. Carlen, C.H. Mastrangelo, Electrothermally actuated inline microfluidic valve Sensors and Actuators, A: Physical, 104 (3), 275-282, (2003).
  2. S. Mutlu, C. Yu, P. Selvaganapathy, F. Svec, C.H. Mastrangelo, J.M.J. Frechet, Micromachined porous polymer for bubble free electro-osmotic pump, Proc. of the 15th IEEE International Conference on MicroElectroMechanical Systems (MEMS), 19 -23, (2002). 
  3. C. Yu, S. Mutlu, P. Selvaganapathy, C.H. Mastrangelo, F. Svec, J.M.J. Frechet, Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers, Analytical Chemistry, 75 (8), 1958-1961, (2003).
  4. W. Wu, K. Sask , J. Brash, P.R, Selvaganapathy, Polyurethane-Based Microfluidic Devices for Blood Contacting Applications, Lab on Chip, 12, 960-970, (2012)
  5. P. Selvaganapathy, Y.S. Leung Ki, P. Renaud, C.H. Mastrangelo, Bubble-free electrokinetic pumping, Journal of Microelectromechanical Systems, 11 (5), 448 -453, (2002).
  6. B. Mitra, C.G. Wilson, L. Que, P. Selvaganapathy, Y.G. Gianchandani, Microfluidic discharge-based optical sources for detection of biochemicals, Lab on a Chip, 6 (1), 60–65, (2006).
  7. P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Effect of electrode asymmetry on performance of electrohydrodynamic micropumps, Journal of Microelectromechanical Systems, 18 (3), 547-554, (2009)
  8. P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Electrohydrodynamic micropumps with asymmetric electrode geometries for microscale electronics cooling, IEEE Transactions on Dielectrics and Electrical Insulation, 16 (2), 483-488, (2009) 
  9. P. Zangeneh, P. Selvaganapathy, C.Y. Ching, Influence of  3D geometry and spacing on the performance of ion drag electrohydrodynamic micropump, Journal of Electrostatics, (2010) (accepted)
  10. M.W. Shinwari, M.J. Deen, P. Selvaganapathy, Analytic Modeling of Biotransistors, IET Circuits, Devices & Systems 2(1), 158-165, 2008.
  11. S. Upadhyaya, P. Selvaganapathy, Nanoporous device for accurate dose control in high throughput screening, in Proc. of ASME/IEEE MEMS 2008 Conference, Tucson, Arizona, 583-586, (2008)
  12. A. Noori, P. Selvaganapathy, Single cell microinjection using compliant fluidic channels, in The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2008), San Diego, California, 1971-1973, 2008. (Top 6% of papers submitted)
  13. A. Noori, P. Selvaganapathy, J. Wilson, Single cell microinjection using compliant fluidic channels with electroosmotic dosing, Lab on a Chip, 9, 3202 – 3211, (2009) (Inside cover article)
  14. P. Rezai, A. Siddiqui, P. Selvaganapathy, B. Gupta, Electrotaxis of C.elegans in a microfluidic environment, Lab on a Chip, 10, 220 – 226, (2010)
  15. P. Rezai, A. Siddiqui, P. Selvaganapathy, B. Gupta, Behavior of Caenorhabditis elegans in Alternating Electric Field and its Application to their Localization and Control, Applied Physics Letters, 96, 153702 (2010)
  16. P. Rezai, S. Salam, P.R. Selvaganapathy, B. Gupta, Electrical sorting of Caenorhabditis elegans, Lab on Chip, 12, 1831-1840, (2012)
  17. G. Mahadevan, P. Selvaganapathy, H. Sheardown, Integrated microneedle arrays and assembly techniques for drug delivery applications, in Proc. of Smart Systems Integration Conference, Barcelona, Spain, 483-486, (2008)